Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.
Peptide A
Muscle Growth
Endogenous activin/myostatin binding protein — the gene-therapy myostatin inhibitor.
Peptide B
Muscle Growth
Long-acting IGF-1 analog with reduced binding-protein affinity for sustained signaling.
Typical vial
1 mg
Typical dose
100-300 mcg
Half-life
~30 minutes (recombinant); years (AAV expression)
FDA status
Not FDA approved as recombinant protein. AAV-Follistatin gen…
Typical vial
1 mg
Typical dose
20-50 mcg
Half-life
~20-30 hours
FDA status
Not FDA approved. Native recombinant rhIGF-1 (mecasermin/Inc…
Follistatin effects
IGF-1 LR3 effects
Follistatin side effects
IGF-1 LR3 side effects
Follistatin dosing ranges
Research / muscle hypertrophy (recombinant)
100-300 mcg · Daily (SubQ) · 10-30 days per cycle
AAV gene therapy (clinical)
Single high-titer AAV infusion · One-time · Durable expression (years)
IGF-1 LR3 dosing ranges
Research / muscle hypertrophy
20-50 mcg · Once daily (SubQ or IM), pre- or post-workout · 30-50 days per cycle
Site-specific injection (research)
20-40 mcg per site · Into trained muscle, post-workout · 30-50 days per cycle
Follistatin: Endogenous activin/myostatin binding protein — the gene-therapy myostatin inhibitor. Typical dose 100-300 mcg. IGF-1 LR3: Long-acting IGF-1 analog with reduced binding-protein affinity for sustained signaling. Typical dose 20-50 mcg. Both fall under the Muscle Growth category.
Stacking Follistatin with IGF-1 LR3 is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.
Follistatin is typically dosed: Daily (SubQ) for Research / muscle hypertrophy (recombinant); One-time for AAV gene therapy (clinical). IGF-1 LR3 is typically dosed: Once daily (SubQ or IM), pre- or post-workout for Research / muscle hypertrophy; Into trained muscle, post-workout for Site-specific injection (research).
Follistatin: Not FDA approved as recombinant protein. AAV-Follistatin gene therapy in clinical trials. IGF-1 LR3: Not FDA approved. Native recombinant rhIGF-1 (mecasermin/Increlex) is FDA approved for severe primary IGF-1 deficiency in children, but IGF-1 LR3 itself is not.
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