PinnyPeptide

Hexarelin vs Ipamorelin

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

Hexarelin

Growth Hormone

The most potent GHRP — strong GH release with documented cardioprotective signaling.

Peptide B

Ipamorelin

Growth Hormone

Selective growth hormone secretagogue with minimal side effects.

Typical vial

5 mg

Typical dose

100 mcg

Half-life

~55 minutes

FDA status

Not FDA approved for any indication.

Typical vial

5 mg

Typical dose

100-300 mcg

Half-life

~2 hours

FDA status

Not FDA approved for human use. Clinical development discont…

Hexarelin effects

  • Most potent acute GH release of any GHRP at equivalent doses
  • Documented cardioprotective signaling via CD36 receptor
  • Stimulates IGF-1 elevation over multi-week courses
  • Supports tissue repair and recovery
  • Mild secondary stimulation of ACTH and prolactin

Ipamorelin effects

  • Selectively stimulates growth hormone release
  • Promotes fat metabolism without affecting cortisol
  • Supports lean muscle growth and recovery
  • Improves sleep quality through enhanced GH pulsatility
  • Does not significantly increase appetite or prolactin

Hexarelin side effects

  • Strongest cortisol and prolactin elevation of the GHRPs
  • Pronounced water retention
  • Lethargy and fatigue with chronic use
  • Rapid tachyphylaxis (response diminishes after 3-4 weeks)
  • Mild appetite stimulation

Ipamorelin side effects

  • Mild head rush or flushing immediately after injection
  • Transient water retention
  • Injection site irritation
  • Occasional lightheadedness

Hexarelin dosing ranges

Short-course GH stimulation

100 mcg · Two to three times daily (SubQ) · 4 weeks maximum, then 4-week break

Combined with CJC-1295 (Mod GRF)

100 mcg of each · Two to three times daily · 4 weeks on / 4 weeks off

Cardioprotective research

1-2 mcg/kg · Per protocol (research-only) · Variable

Ipamorelin dosing ranges

GH optimization and anti-aging

100-300 mcg · Two to three times daily (SubQ) · 8-12 weeks

Combined with CJC-1295 (Mod GRF)

100-200 mcg · Two to three times daily · 8-12 weeks

Full Hexarelin guide → Full Ipamorelin guide →

Hexarelin vs Ipamorelin — common questions

What is the difference between Hexarelin and Ipamorelin?

Hexarelin: The most potent GHRP — strong GH release with documented cardioprotective signaling. Typical dose 100 mcg. Ipamorelin: Selective growth hormone secretagogue with minimal side effects. Typical dose 100-300 mcg. Both fall under the Growth Hormone category.

Can you stack Hexarelin and Ipamorelin?

Stacking Hexarelin with Ipamorelin is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, Hexarelin or Ipamorelin?

Hexarelin is typically dosed: Two to three times daily (SubQ) for Short-course GH stimulation; Two to three times daily for Combined with CJC-1295 (Mod GRF); Per protocol (research-only) for Cardioprotective research. Ipamorelin is typically dosed: Two to three times daily (SubQ) for GH optimization and anti-aging; Two to three times daily for Combined with CJC-1295 (Mod GRF).

Are Hexarelin and Ipamorelin FDA approved?

Hexarelin: Not FDA approved for any indication. Ipamorelin: Not FDA approved for human use. Clinical development discontinued by Novo Nordisk.

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