Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.
Peptide A
Muscle Growth
Long-acting IGF-1 analog with reduced binding-protein affinity for sustained signaling.
Peptide B
Growth Hormone
A locally-acting IGF-1 splice variant released by muscle in response to mechanical load.
Typical vial
1 mg
Typical dose
20-50 mcg
Half-life
~20-30 hours
FDA status
Not FDA approved. Native recombinant rhIGF-1 (mecasermin/Inc…
Typical vial
2 mg
Typical dose
200-400 mcg
Half-life
~5-7 minutes (MGF); ~2-3 days (PEG-MGF)
FDA status
Not FDA approved for any indication.
IGF-1 LR3 effects
MGF (Mechano Growth Factor) effects
IGF-1 LR3 side effects
MGF (Mechano Growth Factor) side effects
IGF-1 LR3 dosing ranges
Research / muscle hypertrophy
20-50 mcg · Once daily (SubQ or IM), pre- or post-workout · 30-50 days per cycle
Site-specific injection (research)
20-40 mcg per site · Into trained muscle, post-workout · 30-50 days per cycle
MGF (Mechano Growth Factor) dosing ranges
Localized muscle repair (non-pegylated)
200-300 mcg per site · Post-workout, into the worked muscle (intramuscular) · 3-4 weeks per cycle
Systemic muscle recovery (PEG-MGF)
200-400 mcg · Twice weekly (SubQ) · 4-6 weeks per cycle
IGF-1 LR3: Long-acting IGF-1 analog with reduced binding-protein affinity for sustained signaling. Typical dose 20-50 mcg. MGF (Mechano Growth Factor): A locally-acting IGF-1 splice variant released by muscle in response to mechanical load. Typical dose 200-400 mcg. Both fall under the Muscle Growth and Growth Hormone categories.
Stacking IGF-1 LR3 with MGF (Mechano Growth Factor) is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.
IGF-1 LR3 is typically dosed: Once daily (SubQ or IM), pre- or post-workout for Research / muscle hypertrophy; Into trained muscle, post-workout for Site-specific injection (research). MGF (Mechano Growth Factor) is typically dosed: Post-workout, into the worked muscle (intramuscular) for Localized muscle repair (non-pegylated); Twice weekly (SubQ) for Systemic muscle recovery (PEG-MGF).
IGF-1 LR3: Not FDA approved. Native recombinant rhIGF-1 (mecasermin/Increlex) is FDA approved for severe primary IGF-1 deficiency in children, but IGF-1 LR3 itself is not. MGF (Mechano Growth Factor): Not FDA approved for any indication.
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