PinnyPeptide

FTPP-Adipotide vs Retatrutide

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

FTPP-Adipotide

Weight Management

Vasculature-targeting peptide that selectively destroys adipose blood vessels.

Peptide B

Retatrutide

Weight Management

Lilly's triple-agonist of GLP-1, GIP, and glucagon receptors — the strongest weight-loss data yet reported.

Typical vial

5 mg

Typical dose

Per kg dosing (research-only) mcg

Half-life

~hours

FDA status

Not FDA approved.

Typical vial

10 mg

Typical dose

500-12000 mcg

Half-life

~6 days (~144 hours)

FDA status

Not FDA approved. In Phase 3 clinical trials (TRIUMPH progra…

FTPP-Adipotide effects

  • Selective destruction of white adipose tissue vasculature
  • Rapid weight and fat loss in primate models
  • Improved insulin sensitivity
  • Brown adipose tissue largely spared
  • Mechanism distinct from lipolytic / appetite-suppressing peptides

Retatrutide effects

  • Triple receptor agonism: GLP-1, GIP, and glucagon
  • Mean ~24% weight loss at 12 mg weekly (Phase 2, 48 weeks)
  • Appetite suppression and delayed gastric emptying (GLP-1 / GIP)
  • Increased energy expenditure and hepatic fat oxidation (glucagon arm)
  • Improved glycemic control in type 2 diabetes
  • Reduction in hepatic fat content (MASH-relevant)

FTPP-Adipotide side effects

  • Renal toxicity (prohibitin expressed in kidney vasculature) — significant safety concern
  • Possible damage to other prohibitin-expressing vascular beds
  • Injection-site reactions
  • Limited human safety data
  • Acute inflammatory response from adipose vascular death

Retatrutide side effects

  • Gastrointestinal: nausea, vomiting, diarrhea (most common, dose-dependent)
  • Decreased appetite (intended)
  • Constipation
  • Increased heart rate (glucagon-mediated, dose-dependent)
  • Injection-site reactions
  • Risk of pancreatitis (incretin-class concern)
  • Theoretical: thyroid C-cell tumors (incretin-class warning — animal data)
  • Hyperglycemia risk if dose-titration is too rapid (glucagon arm)

FTPP-Adipotide dosing ranges

Animal research (rhesus monkey model)

0.43 mg/kg · Daily SubQ × 28 days · Per published protocol

Human self-experimentation

Not recommended · — · —

Retatrutide dosing ranges

Obesity / weight loss (Phase 2 / 3 protocol)

1-12 mg · Once weekly (SubQ), dose-titrated · Long-term per clinical protocol

Self-experimentation (no clinical guidance)

0.5 mg start, titrate to tolerance · Once weekly · Long-term with careful titration

FTPP-Adipotide vs Retatrutide — common questions

What is the difference between FTPP-Adipotide and Retatrutide?

FTPP-Adipotide: Vasculature-targeting peptide that selectively destroys adipose blood vessels. Typical dose Per kg dosing (research-only) mcg. Retatrutide: Lilly's triple-agonist of GLP-1, GIP, and glucagon receptors — the strongest weight-loss data yet reported. Typical dose 500-12000 mcg. Both fall under the Weight Management category.

Can you stack FTPP-Adipotide and Retatrutide?

Stacking FTPP-Adipotide with Retatrutide is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, FTPP-Adipotide or Retatrutide?

FTPP-Adipotide is typically dosed: Daily SubQ × 28 days for Animal research (rhesus monkey model); — for Human self-experimentation. Retatrutide is typically dosed: Once weekly (SubQ), dose-titrated for Obesity / weight loss (Phase 2 / 3 protocol); Once weekly for Self-experimentation (no clinical guidance).

Are FTPP-Adipotide and Retatrutide FDA approved?

FTPP-Adipotide: Not FDA approved. Retatrutide: Not FDA approved. In Phase 3 clinical trials (TRIUMPH program for obesity, SYNERGY-NASH for MASH). FDA submission anticipated 2026-2027 pending Phase 3 readouts.

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