PinnyPeptide

AOD-9604 vs Retatrutide

Side-by-side comparison: effects, dosing ranges, side effects, regulatory status, and reconstitution.

Peptide A

AOD-9604

Weight Management

Fat-metabolizing fragment of human growth hormone without growth-promoting effects.

Peptide B

Retatrutide

Weight Management

Lilly's triple-agonist of GLP-1, GIP, and glucagon receptors — the strongest weight-loss data yet reported.

Typical vial

5 mg

Typical dose

250-500 mcg

Half-life

~30-60 minutes

FDA status

Not FDA approved as a drug. Granted GRAS status as a food ad…

Typical vial

10 mg

Typical dose

500-12000 mcg

Half-life

~6 days (~144 hours)

FDA status

Not FDA approved. In Phase 3 clinical trials (TRIUMPH progra…

AOD-9604 effects

  • Stimulates lipolysis (fat breakdown) in adipose tissue
  • Inhibits lipogenesis (new fat formation)
  • Does not affect blood glucose or insulin levels
  • Does not elevate IGF-1 or bind the GH receptor
  • May support cartilage repair (emerging research)

Retatrutide effects

  • Triple receptor agonism: GLP-1, GIP, and glucagon
  • Mean ~24% weight loss at 12 mg weekly (Phase 2, 48 weeks)
  • Appetite suppression and delayed gastric emptying (GLP-1 / GIP)
  • Increased energy expenditure and hepatic fat oxidation (glucagon arm)
  • Improved glycemic control in type 2 diabetes
  • Reduction in hepatic fat content (MASH-relevant)

AOD-9604 side effects

  • Injection site irritation or redness
  • Occasional headache
  • Mild nausea (uncommon)
  • Transient lightheadedness

Retatrutide side effects

  • Gastrointestinal: nausea, vomiting, diarrhea (most common, dose-dependent)
  • Decreased appetite (intended)
  • Constipation
  • Increased heart rate (glucagon-mediated, dose-dependent)
  • Injection-site reactions
  • Risk of pancreatitis (incretin-class concern)
  • Theoretical: thyroid C-cell tumors (incretin-class warning — animal data)
  • Hyperglycemia risk if dose-titration is too rapid (glucagon arm)

AOD-9604 dosing ranges

Fat loss and body composition

250-500 mcg · Once daily (SubQ) · 8-12 weeks

Retatrutide dosing ranges

Obesity / weight loss (Phase 2 / 3 protocol)

1-12 mg · Once weekly (SubQ), dose-titrated · Long-term per clinical protocol

Self-experimentation (no clinical guidance)

0.5 mg start, titrate to tolerance · Once weekly · Long-term with careful titration

AOD-9604 vs Retatrutide — common questions

What is the difference between AOD-9604 and Retatrutide?

AOD-9604: Fat-metabolizing fragment of human growth hormone without growth-promoting effects. Typical dose 250-500 mcg. Retatrutide: Lilly's triple-agonist of GLP-1, GIP, and glucagon receptors — the strongest weight-loss data yet reported. Typical dose 500-12000 mcg. Both fall under the Weight Management category.

Can you stack AOD-9604 and Retatrutide?

Stacking AOD-9604 with Retatrutide is a protocol-design question best raised with a clinician — it depends on your goal, current bloodwork, and whether both peptides target overlapping mechanisms. Both peptides should be tracked independently with separate injection sites and timing. PinnyPeptide supports multi-peptide stacks with automatic injection site rotation.

Which is dosed more frequently, AOD-9604 or Retatrutide?

AOD-9604 is typically dosed: Once daily (SubQ) for Fat loss and body composition. Retatrutide is typically dosed: Once weekly (SubQ), dose-titrated for Obesity / weight loss (Phase 2 / 3 protocol); Once weekly for Self-experimentation (no clinical guidance).

Are AOD-9604 and Retatrutide FDA approved?

AOD-9604: Not FDA approved as a drug. Granted GRAS status as a food additive in 2014. Retatrutide: Not FDA approved. In Phase 3 clinical trials (TRIUMPH program for obesity, SYNERGY-NASH for MASH). FDA submission anticipated 2026-2027 pending Phase 3 readouts.

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